| Rank | Total Population ▼ | School District / Population |
| 1. | 466,178 | Greenville County School District / 466,178 |
| 2. | 350,209 | Charleston County School District / 350,209 |
| 3. | 269,291 | Horry County School District / 269,291 |
| 4. | 201,528 | Richland School District 1 / 201,528 |
| 5. | 177,843 | Berkeley County School District / 177,843 |
| 6. | 162,758 | Aiken County School District / 162,758 |
| 7. | 161,206 | Beaufort County School District / 161,206 |
| 8. | 126,150 | Richland School District 2 / 126,150 |
| 9. | 121,030 | Lexington School District 1 / 121,030 |
| 10. | 119,266 | Dorchester School District 2 / 119,266 |
| 11. | 119,224 | Pickens County School District / 119,224 |
| 12. | 110,728 | York School District 3 / 110,728 |
| 13. | 96,463 | Florence School District 1 / 96,463 |
| 14. | 91,018 | Lexington School District 5 / 91,018 |
| 15. | 78,592 | Anderson School District 5 / 78,592 |
| 16. | 76,652 | Lancaster County School District / 76,652 |
| 17. | 74,273 | Oconee County School District / 74,273 |
| 18. | 68,681 | Darlington County School District / 68,681 |
| 19. | 63,322 | Lexington School District 2 / 63,322 |
| 20. | 61,697 | Kershaw County School District / 61,697 |
| 21. | 60,158 | Georgetown County School District / 60,158 |
| 22. | 58,872 | Greenwood School District 50 / 58,872 |
| 23. | 58,687 | Spartanburg School District 6 / 58,687 |
| 24. | 58,308 | Spartanburg School District 2 / 58,308 |
| 25. | 57,252 | Sumter School District 2 / 57,252 |
| 26. | 53,383 | Cherokee County School District / 53,383 |
| 27. | 52,943 | Spartanburg School District 7 / 52,943 |
| 28. | 51,950 | Orangeburg School District 5 / 51,950 |
| 29. | 50,204 | Sumter School District 17 / 50,204 |
| 30. | 49,865 | York School District 4 / 49,865 |
| 31. | 49,808 | Anderson School District 1 / 49,808 |
| 32. | 46,734 | Chesterfield County School District / 46,734 |
| 33. | 41,867 | Spartanburg School District 5 / 41,867 |
| 34. | 38,892 | Colleton County School District / 38,892 |
| 35. | 37,508 | Newberry County School District / 37,508 |
| 36. | 37,250 | Laurens School District 55 / 37,250 |
| 37. | 34,423 | Williamsburg County School District / 34,423 |
| 38. | 34,368 | York School District 2 / 34,368 |
| 39. | 33,140 | Chester County School District / 33,140 |
| 40. | 31,112 | York School District 1 / 31,112 |
| 41. | 30,439 | Spartanburg School District 1 / 30,439 |
| 42. | 28,961 | Union County School District / 28,961 |
| 43. | 28,933 | Marlboro County School District / 28,933 |
| 44. | 26,985 | Edgefield County School District / 26,985 |
| 45. | 24,777 | Jasper County School District / 24,777 |
| 46. | 24,326 | Abbeville County School District / 24,326 |
| 47. | 23,956 | Fairfield County School District / 23,956 |
| 48. | 22,394 | Anderson School District 2 / 22,394 |
| 49. | 21,359 | Anderson School District 4 / 21,359 |
| 50. | 20,726 | Laurens School District 56 / 20,726 |
| 51. | 20,584 | Florence School District 3 / 20,584 |
| 52. | 20,430 | Orangeburg School District 4 / 20,430 |
| 53. | 20,121 | Orangeburg School District 3 / 20,121 |
| 54. | 19,243 | Clarendon School District 2 / 19,243 |
| 55. | 19,220 | Lee County School District / 19,220 |
| 56. | 18,998 | Dillon School District 2 / 18,998 |
| 57. | 18,439 | Spartanburg School District 4 / 18,439 |
| 58. | 18,306 | Lexington School District 4 / 18,306 |
| 59. | 17,289 | Dorchester School District 4 / 17,289 |
| 60. | 16,629 | Spartanburg School District 3 / 16,629 |
| 61. | 15,337 | Marion School District 1 / 15,337 |
| 62. | 15,200 | Saluda County School District / 15,200 |
| 63. | 15,175 | Calhoun County School District / 15,175 |
| 64. | 15,156 | Anderson School District 3 / 15,156 |
| 65. | 14,309 | Richland County School District 2 within Fort Jackson / 14,309 |
| 65. | 14,309 | Fort Jackson Schools / 14,309 |
| 67. | 13,703 | Hampton School District 1 / 13,703 |
| 68. | 13,248 | Lexington School District 3 / 13,248 |
| 69. | 12,382 | Barnwell School District 45 / 12,382 |
| 70. | 11,648 | Marion School District 2 / 11,648 |
| 71. | 10,419 | Allendale County School District / 10,419 |
| 72. | 10,233 | McCormick County School District / 10,233 |
| 73. | 8,920 | Clarendon School District 1 / 8,920 |
| 74. | 8,810 | Bamberg School District 1 / 8,810 |
| 75. | 7,602 | Dillon School District 3 / 7,602 |
| 76. | 7,387 | Hampton School District 2 / 7,387 |
| 77. | 7,366 | Greenwood School District 52 / 7,366 |
| 78. | 7,177 | Bamberg School District 2 / 7,177 |
| 79. | 7,127 | Florence School District 2 / 7,127 |
| 80. | 6,893 | Greenwood School District 51 / 6,893 |
| 81. | 6,808 | Clarendon School District 3 / 6,808 |
| 82. | 6,768 | Florence School District 4 / 6,768 |
| 83. | 6,077 | Marion School District 7 / 6,077 |
| 84. | 5,943 | Florence School District 5 / 5,943 |
| 85. | 5,462 | Dillon School District 1 / 5,462 |
| 86. | 5,135 | Barnwell School District 29 / 5,135 |
| 87. | 5,096 | Barnwell School District 19 / 5,096 |
| 88. | 1,027 | Beaufort County School District within Beaufort Marine Corps Air Station / 1,027 |
| 88. | 1,027 | Beaufort Marine Corps Air Station School District / 1,027 |
Please note that we only rank locations with 'Total Population' data. The rank above might not be a complete list. Locations without 'Total Population' data are not listed.
