| Rank | Median Household Income ▼ | School District / Population |
| 1. | $61,500 | Altenburg 48 School District / 1,229 |
| 2. | $54,801 | Giant City Community Consolidated School District 130 / 2,678 |
| 3. | $53,125 | Lick Creek Community Consolidated School District 16 / 1,520 |
| 4. | $52,885 | Leopold R-III School District / 1,040 |
| 5. | $52,797 | Jackson R-II School District / 30,817 |
| 6. | $52,454 | Nell Holcomb R-IV School District / 3,090 |
| 7. | $49,890 | Perry County 32 School District / 17,601 |
| 8. | $49,375 | Oran R-III School District / 2,226 |
| 9. | $49,167 | Oak Ridge R-VI School District / 1,979 |
| 10. | $48,750 | Dongola School Unit District 66 / 2,027 |
| 11. | $48,542 | Kelso C-7 School District / 2,019 |
| 12. | $48,370 | Carterville Community Unit School District 5 / 11,927 |
| 13. | $48,177 | Marion Community Unit School District 2 / 27,844 |
| 14. | $47,177 | Trico Community Unit School District 176 / 6,317 |
| 15. | $46,452 | Steeleville Community Unit School District 138 / 3,126 |
| 16. | $45,944 | Chester Community Unit School District 139 / 11,183 |
| 17. | $44,476 | New Simpson Hill Consolidated District 32 / 2,765 |
| 18. | $44,395 | Ste. Genevieve County R-II School District / 14,939 |
| 19. | $44,236 | Scott County R-IV School District / 6,061 |
| 20. | $43,996 | Goreville Community Unit School District 1 / 3,882 |
| 21. | $43,076 | Anna Jonesboro Community High School District 81 / 10,764 |
| 21. | $43,076 | Anna Community Consolidated School District 37 / 6,410 |
| 23. | $42,852 | Ballard County School District / 8,274 |
| 24. | $42,500 | Joppa-Maple Grove Unit District 38 / 1,492 |
| 25. | $42,455 | Farmington R-7 School District / 28,589 |
| 26. | $42,321 | Buncombe Consolidated School District 43 / 721 |
| 27. | $42,216 | De Soto Consolidated School District 86 / 1,900 |
| 28. | $41,923 | Scott County Central Schools / 2,003 |
| 29. | $41,250 | Advance R-IV School District / 3,072 |
| 30. | $41,172 | Delta R-V School District / 2,127 |
| 31. | $40,668 | Meadow Heights R-II School District / 3,598 |
| 32. | $40,625 | Elverado Community Unit School District 196 / 2,981 |
| 33. | $40,306 | Cape Girardeau 63 School District / 39,078 |
| 34. | $40,273 | Bloomfield School District / 4,568 |
| 35. | $40,227 | Richland R-I School District / 1,711 |
| 36. | $40,217 | Vienna High School District 133 / 8,921 |
| 37. | $39,401 | Herrin Community Unit School District 4 / 16,423 |
| 38. | $39,375 | Puxico R-VIII School District / 4,567 |
| 39. | $38,795 | Vienna School District 55 / 4,547 |
| 40. | $37,609 | Cobden School Unit District 17 / 3,899 |
| 41. | $37,579 | Fredericktown R-I School District / 10,846 |
| 42. | $37,567 | Murphysboro Community Unit School District 186 / 15,544 |
| 43. | $37,421 | Dexter R-XI School District / 12,886 |
| 44. | $37,337 | Sikeston School District / 20,851 |
| 45. | $36,842 | Bell City R-II School District / 1,410 |
| 46. | $36,734 | Century Community Unit School District 100 / 2,442 |
| 47. | $36,719 | Zeigler-Royalton Community Unit School District 188 / 4,186 |
| 48. | $35,363 | Du Quoin Community Unit School District 300 / 9,591 |
| 49. | $34,755 | Shawnee Community Unit School District 84 / 2,425 |
| 50. | $34,732 | Cypress School District 64 / 888 |
| 51. | $34,643 | Marquand-Zion School District / 1,395 |
| 52. | $34,331 | Jonesboro Community Consolidated School District 43 / 2,834 |
| 53. | $33,355 | Greenville R-II School District / 5,349 |
| 54. | $33,284 | Meridian Community Unit School District 101 / 3,649 |
| 55. | $33,036 | Unity Point Community Consolidated School District 140 / 5,438 |
| 56. | $33,018 | Egyptian Community Unit School District 5 / 3,709 |
| 57. | $32,632 | Scott City R-I School District / 5,373 |
| 58. | $32,344 | Zalma R-V School District / 1,578 |
| 59. | $31,588 | Woodland R-IV School District / 5,825 |
| 60. | $30,375 | Scott County R-II School District / 3,581 |
| 61. | $28,761 | Charleston R-I School District / 8,513 |
| 62. | $27,100 | East Prairie R-II School District / 5,763 |
| 63. | $26,035 | Carbondale Community High School District 165 / 37,544 |
| 64. | $20,324 | Carbondale Elementary School District 95 / 27,528 |
| 65. | $16,727 | Cairo Community Unit School District 1 / 2,950 |
Please note that we only rank locations with 'Median Household Income' data. The rank above might not be a complete list. Locations without 'Median Household Income' data are not listed.
