| Rank | United States American as First Ancestry Population Percentage ▼ | School District / Population |
| 1. | 31.2% | Kershaw County School District / 62,342 |
| 2. | 30.7% | Greenwood School District 52 / 7,364 |
| 3. | 28.5% | Barnwell School District 29 / 5,368 |
| 4. | 28.0% | Anderson School District 3 / 15,039 |
| 5. | 28.0% | Greenwood School District 51 / 7,101 |
| 6. | 27.5% | Barnwell School District 45 / 11,915 |
| 7. | 26.9% | Aiken County School District / 165,978 |
| 8. | 26.1% | Lee County School District / 18,708 |
| 9. | 25.9% | Dorchester School District 4 / 16,296 |
| 10. | 25.6% | Colleton County School District / 38,247 |
| 11. | 24.6% | Anderson School District 2 / 23,295 |
| 12. | 23.5% | Fairfield County School District / 23,382 |
| 13. | 23.5% | Bamberg School District 1 / 8,611 |
| 14. | 23.0% | Chester County School District / 32,708 |
| 15. | 22.6% | Lancaster County School District / 79,515 |
| 16. | 22.2% | Saluda County School District / 15,250 |
| 17. | 22.2% | Abbeville County School District / 23,891 |
| 18. | 21.7% | Spartanburg School District 1 / 29,714 |
| 19. | 21.5% | Newberry County School District / 37,593 |
| 20. | 21.2% | Chesterfield County School District / 46,333 |
| 21. | 21.1% | Greenwood School District 50 / 58,892 |
| 22. | 21.0% | Cherokee County School District / 53,716 |
| 23. | 20.9% | Edgefield County School District / 26,573 |
| 24. | 20.6% | Dillon School District 3 / 8,077 |
| 25. | 20.2% | Spartanburg School District 4 / 18,504 |
| 26. | 20.1% | Dorchester School District 2 / 126,476 |
| 27. | 19.8% | Spartanburg School District 3 / 16,307 |
| 28. | 19.5% | Clarendon School District 3 / 6,573 |
| 29. | 19.4% | Lexington School District 3 / 12,749 |
| 30. | 19.3% | Anderson School District 1 / 49,874 |
| 31. | 19.1% | Anderson School District 4 / 21,928 |
| 32. | 18.6% | Barnwell School District 19 / 5,004 |
| 33. | 18.5% | Spartanburg School District 2 / 58,913 |
| 34. | 18.0% | Union County School District / 28,329 |
| 35. | 17.8% | Laurens School District 56 / 20,894 |
| 36. | 17.7% | Orangeburg School District 4 / 20,108 |
| 37. | 17.6% | York School District 1 / 32,570 |
| 38. | 17.5% | Hampton School District 1 / 13,195 |
| 39. | 17.3% | Lexington School District 4 / 18,396 |
| 40. | 17.0% | Oconee County School District / 74,656 |
| 41. | 16.8% | Lexington School District 1 / 126,307 |
| 42. | 16.7% | Pickens County School District / 119,577 |
| 43. | 16.4% | Laurens School District 55 / 36,736 |
| 44. | 15.9% | Horry County School District / 283,280 |
| 45. | 15.8% | Florence School District 5 / 5,213 |
| 46. | 15.5% | Dillon School District 2 / 23,452 |
| 47. | 15.5% | Anderson School District 5 / 79,906 |
| 48. | 15.4% | York School District 2 / 36,439 |
| 49. | 14.8% | Darlington County School District / 68,161 |
| 50. | 14.3% | Florence School District 2 / 6,878 |
| 51. | 14.2% | Spartanburg School District 5 / 42,810 |
| 52. | 13.8% | Charleston County School District / 365,674 |
| 53. | 13.5% | Name N/A / 107,782 |
| 54. | 13.3% | Greenville County School District / 482,484 |
| 55. | 13.2% | Lexington School District 5 / 93,939 |
| 55. | 13.2% | Richland County School District 2 within Fort Jackson / 14,761 |
| 55. | 13.2% | Fort Jackson Schools / 14,761 |
| 58. | 13.1% | Lexington School District 2 / 63,624 |
| 59. | 13.0% | Berkeley County School District / 188,835 |
| 59. | 13.0% | Clarendon School District 2 / 18,553 |
| 61. | 12.9% | Georgetown County School District / 60,389 |
| 62. | 12.5% | Name N/A / 15,710 |
| 63. | 12.4% | Florence School District 3 / 19,559 |
| 64. | 12.3% | Calhoun County School District / 15,031 |
| 65. | 11.8% | Clarendon School District 1 / 9,313 |
| 66. | 11.8% | Bamberg School District 2 / 7,038 |
| 67. | 11.7% | Spartanburg School District 6 / 61,345 |
| 68. | 11.6% | Name N/A / 32,411 |
| 69. | 11.5% | Marlboro County School District / 28,294 |
| 70. | 10.6% | York School District 4 / 54,198 |
| 71. | 10.2% | McCormick County School District / 10,003 |
| 72. | 10.1% | Spartanburg School District 7 / 53,770 |
| 73. | 9.5% | Florence School District 1 / 100,376 |
| 74. | 9.4% | Richland School District 2 / 128,949 |
| 75. | 9.4% | York School District 3 / 112,078 |
| 76. | 8.9% | Orangeburg School District 5 / 50,688 |
| 77. | 8.7% | Williamsburg County School District / 33,560 |
| 78. | 8.7% | Allendale County School District / 10,027 |
| 79. | 8.2% | Jasper County School District / 26,042 |
| 80. | 7.3% | Orangeburg School District 3 / 20,466 |
| 81. | 7.0% | Beaufort County School District / 167,504 |
| 82. | 7.0% | Richland School District 1 / 206,981 |
| 83. | 6.3% | Florence School District 4 / 6,032 |
| 84. | 5.8% | Hampton School District 2 / 7,475 |
| 85. | 0.4% | Beaufort County School District within Beaufort Marine Corps Air Station / 949 |
| 85. | 0.4% | Beaufort Marine Corps Air Station School District / 949 |
Please note that we only rank locations with 'United States American as First Ancestry Population Percentage' data. The rank above might not be a complete list. Locations without 'United States American as First Ancestry Population Percentage' data are not listed.
