| Rank | United States American as First Ancestry Population Percentage ▼ | School District / Population |
| 1. | 38.6% | Kershaw County School District / 61,583 |
| 2. | 38.4% | Lee County School District / 19,160 |
| 3. | 32.0% | Anderson School District 3 / 15,254 |
| 4. | 29.6% | Anderson School District 2 / 23,015 |
| 5. | 29.5% | Colleton County School District / 38,665 |
| 6. | 28.5% | Greenwood School District 52 / 7,401 |
| 7. | 27.9% | Aiken County School District / 163,435 |
| 8. | 26.1% | Dillon School District 1 / 5,071 |
| 9. | 25.6% | Lancaster County School District / 76,364 |
| 10. | 24.8% | Dorchester School District 4 / 16,492 |
| 11. | 24.4% | Dillon School District 3 / 8,362 |
| 12. | 24.0% | Fairfield County School District / 23,804 |
| 13. | 23.2% | Anderson School District 1 / 49,105 |
| 14. | 22.8% | Chester County School District / 33,028 |
| 15. | 22.5% | Spartanburg School District 1 / 30,441 |
| 16. | 22.4% | Cherokee County School District / 52,964 |
| 17. | 22.1% | Spartanburg School District 3 / 16,282 |
| 18. | 21.8% | Anderson School District 4 / 21,169 |
| 19. | 21.4% | Greenwood School District 51 / 7,275 |
| 20. | 21.3% | Spartanburg School District 4 / 18,664 |
| 21. | 21.0% | Saluda County School District / 14,784 |
| 22. | 20.9% | Greenwood School District 50 / 58,717 |
| 23. | 20.7% | Spartanburg School District 2 / 56,708 |
| 24. | 20.7% | Clarendon School District 3 / 6,481 |
| 25. | 20.5% | Abbeville County School District / 24,417 |
| 26. | 20.3% | Chesterfield County School District / 46,462 |
| 27. | 20.0% | Lexington School District 4 / 17,750 |
| 28. | 18.9% | Barnwell School District 29 / 5,174 |
| 29. | 18.8% | Dorchester School District 2 / 120,344 |
| 30. | 18.1% | Edgefield County School District / 26,763 |
| 31. | 17.9% | Lexington School District 3 / 13,404 |
| 32. | 17.8% | Union County School District / 28,804 |
| 33. | 17.8% | Laurens School District 56 / 19,992 |
| 34. | 17.8% | Anderson School District 5 / 78,966 |
| 35. | 17.1% | Newberry County School District / 37,432 |
| 36. | 17.0% | Pickens County School District / 119,167 |
| 37. | 17.0% | Lexington School District 1 / 118,927 |
| 38. | 16.7% | Bamberg School District 1 / 8,423 |
| 39. | 16.7% | Spartanburg School District 5 / 41,929 |
| 40. | 16.1% | Horry County School District / 270,943 |
| 41. | 16.0% | Barnwell School District 45 / 11,657 |
| 42. | 16.0% | York School District 2 / 33,507 |
| 42. | 16.0% | Oconee County School District / 74,038 |
| 44. | 15.8% | Laurens School District 55 / 37,133 |
| 45. | 15.5% | York School District 1 / 31,234 |
| 46. | 15.5% | Marion School District 2 / 11,704 |
| 47. | 15.1% | Dillon School District 2 / 18,300 |
| 48. | 14.7% | Barnwell School District 19 / 5,692 |
| 49. | 14.6% | Greenville County School District / 468,675 |
| 50. | 14.2% | Orangeburg School District 4 / 20,362 |
| 51. | 14.0% | Calhoun County School District / 15,134 |
| 52. | 13.8% | Lexington School District 5 / 91,853 |
| 53. | 13.7% | Marion School District 7 / 6,254 |
| 53. | 13.7% | Florence School District 5 / 5,849 |
| 55. | 13.5% | McCormick County School District / 10,140 |
| 56. | 13.5% | Hampton School District 1 / 13,602 |
| 57. | 13.4% | Berkeley County School District / 179,773 |
| 58. | 13.2% | Spartanburg School District 6 / 59,270 |
| 59. | 13.0% | Darlington County School District / 68,500 |
| 60. | 12.8% | Lexington School District 2 / 63,422 |
| 61. | 12.7% | Florence School District 2 / 7,248 |
| 62. | 12.6% | Name N/A / 107,279 |
| 63. | 12.1% | Clarendon School District 2 / 19,262 |
| 64. | 12.0% | Florence School District 3 / 19,472 |
| 65. | 11.8% | Marlboro County School District / 28,750 |
| 66. | 11.7% | Charleston County School District / 352,548 |
| 67. | 10.7% | Orangeburg School District 3 / 20,794 |
| 68. | 10.5% | Georgetown County School District / 60,285 |
| 69. | 10.3% | Florence School District 1 / 97,428 |
| 70. | 10.0% | Clarendon School District 1 / 9,003 |
| 71. | 9.8% | Fort Jackson Schools / 13,363 |
| 71. | 9.8% | Richland County School District 2 within Fort Jackson / 13,363 |
| 73. | 9.5% | York School District 3 / 111,296 |
| 74. | 9.4% | York School District 4 / 50,539 |
| 75. | 9.4% | Richland School District 2 / 125,211 |
| 76. | 9.1% | Orangeburg School District 5 / 51,073 |
| 77. | 9.0% | Name N/A / 14,811 |
| 78. | 8.8% | Spartanburg School District 7 / 54,214 |
| 79. | 8.6% | Marion School District 1 / 15,080 |
| 80. | 8.1% | Florence School District 4 / 6,717 |
| 81. | 7.9% | Jasper County School District / 24,792 |
| 82. | 7.2% | Bamberg School District 2 / 7,518 |
| 83. | 7.2% | Richland School District 1 / 204,798 |
| 84. | 6.9% | Williamsburg County School District / 34,361 |
| 85. | 6.7% | Beaufort County School District / 160,868 |
| 86. | 6.1% | Hampton School District 2 / 7,385 |
| 87. | 6.1% | Allendale County School District / 10,399 |
| 88. | 0.7% | Beaufort County School District within Beaufort Marine Corps Air Station / 1,448 |
| 88. | 0.7% | Beaufort Marine Corps Air Station School District / 1,448 |
Please note that we only rank locations with 'United States American as First Ancestry Population Percentage' data. The rank above might not be a complete list. Locations without 'United States American as First Ancestry Population Percentage' data are not listed.
*ACS stands for U.S. Census American Community Survey. According to the U.S. Census, if the date is a range, you can interpret the data as an average of the period of time.
