| Rank | United States American as First Ancestry Population Percentage ▼ | School District / Population |
| 1. | 28.1% | Lancaster County School District / 73,725 |
| 2. | 26.2% | Greenwood School District 52 / 7,158 |
| 3. | 25.6% | Colleton County School District / 39,128 |
| 4. | 25.0% | Anderson School District 3 / 14,288 |
| 5. | 24.6% | Kershaw County School District / 58,176 |
| 6. | 23.9% | Spartanburg School District 1 / 30,279 |
| 7. | 23.5% | Spartanburg School District 2 / 51,997 |
| 8. | 23.2% | Lexington School District 3 / 13,485 |
| 9. | 23.1% | Anderson School District 2 / 22,327 |
| 10. | 22.6% | Saluda County School District / 13,931 |
| 11. | 22.4% | Chesterfield County School District / 42,876 |
| 12. | 21.7% | Cherokee County School District / 52,016 |
| 13. | 21.7% | Dillon School District 3 / 7,147 |
| 14. | 21.6% | Anderson School District 1 / 47,632 |
| 15. | 21.3% | Chester County School District / 32,666 |
| 16. | 21.2% | Spartanburg School District 3 / 17,604 |
| 17. | 21.0% | Pickens County School District / 116,092 |
| 18. | 20.8% | Aiken County School District / 155,496 |
| 19. | 20.1% | Union County School District / 27,800 |
| 20. | 19.7% | Oconee County School District / 70,507 |
| 21. | 19.3% | Lexington School District 4 / 16,453 |
| 22. | 19.3% | Anderson School District 4 / 20,359 |
| 23. | 19.2% | Greenwood School District 50 / 57,633 |
| 24. | 19.0% | Lexington School District 1 / 106,932 |
| 25. | 18.9% | Spartanburg School District 4 / 17,079 |
| 26. | 18.8% | Spartanburg School District 5 / 38,566 |
| 27. | 18.5% | Laurens School District 56 / 20,892 |
| 28. | 18.2% | Fairfield County School District / 23,482 |
| 29. | 18.0% | Abbeville County School District / 23,958 |
| 30. | 17.9% | Greenwood School District 51 / 7,900 |
| 31. | 17.6% | Horry County School District / 248,601 |
| 32. | 17.6% | Lee County School District / 20,074 |
| 33. | 17.6% | Dillon School District 1 / 5,444 |
| 34. | 17.2% | Barnwell School District 45 / 12,032 |
| 35. | 17.0% | Newberry County School District / 37,992 |
| 36. | 16.5% | Spartanburg School District 6 / 59,872 |
| 37. | 16.4% | York School District 1 / 30,491 |
| 38. | 16.4% | Edgefield County School District / 25,469 |
| 39. | 16.0% | Calhoun County School District / 14,746 |
| 40. | 16.0% | Greenville County School District / 444,979 |
| 41. | 15.7% | Dorchester School District 2 / 105,973 |
| 42. | 15.6% | Anderson School District 5 / 75,620 |
| 43. | 15.5% | Florence School District 5 / 5,748 |
| 44. | 15.4% | York School District 2 / 31,589 |
| 45. | 15.1% | Dorchester School District 4 / 16,469 |
| 46. | 14.9% | Florence School District 2 / 6,661 |
| 47. | 14.6% | Laurens School District 55 / 39,947 |
| 48. | 14.0% | Lexington School District 2 / 61,390 |
| 49. | 13.9% | Florence School District 3 / 20,769 |
| 50. | 13.4% | Lexington School District 5 / 88,313 |
| 51. | 13.3% | Barnwell School District 19 / 5,712 |
| 52. | 13.0% | Bamberg School District 1 / 8,015 |
| 53. | 13.0% | Marlboro County School District / 28,571 |
| 54. | 12.6% | Clarendon School District 3 / 5,976 |
| 55. | 12.5% | Clarendon School District 1 / 9,128 |
| 56. | 11.7% | Berkeley County School District / 163,328 |
| 57. | 11.7% | Charleston County School District / 345,714 |
| 58. | 11.4% | Florence School District 1 / 92,226 |
| 59. | 11.4% | Darlington County School District / 66,771 |
| 60. | 11.2% | Florence School District 4 / 6,749 |
| 61. | 10.7% | Georgetown County School District / 60,235 |
| 62. | 10.6% | Orangeburg School District 3 / 19,641 |
| 63. | 10.5% | Marion School District 1 / 16,105 |
| 64. | 10.3% | McCormick County School District / 10,087 |
| 65. | 10.3% | Marion School District 7 / 6,140 |
| 66. | 10.0% | Clarendon School District 2 / 17,759 |
| 67. | 9.9% | Barnwell School District 29 / 5,142 |
| 67. | 9.9% | York School District 4 / 38,688 |
| 69. | 9.6% | York School District 3 / 108,583 |
| 70. | 9.6% | Marion School District 2 / 11,778 |
| 71. | 9.1% | Orangeburg School District 4 / 20,741 |
| 72. | 9.0% | Spartanburg School District 7 / 54,475 |
| 73. | 8.4% | Richland School District 2 / 108,900 |
| 74. | 8.3% | Hampton School District 1 / 13,010 |
| 75. | 8.2% | Sumter School District 2 / 54,577 |
| 76. | 7.9% | Dillon School District 2 / 18,186 |
| 77. | 7.4% | Sumter School District 17 / 49,864 |
| 78. | 7.2% | Allendale County School District / 10,459 |
| 79. | 6.8% | Richland School District 1 / 195,966 |
| 80. | 6.5% | Orangeburg School District 5 / 50,005 |
| 81. | 6.1% | Beaufort County School District / 145,930 |
| 82. | 6.1% | Williamsburg County School District / 34,920 |
| 83. | 4.6% | Hampton School District 2 / 7,987 |
| 84. | 3.1% | Bamberg School District 2 / 7,369 |
| 85. | 2.8% | Richland County School District 2 within Fort Jackson / 14,220 |
| 85. | 2.8% | Fort Jackson Schools / 14,220 |
| 87. | 2.8% | Name N/A / 16,089 |
| 88. | 2.4% | Beaufort Marine Corps Air Station School District / 1,869 |
| 88. | 2.4% | Beaufort County School District within Beaufort Marine Corps Air Station / 1,869 |
| 90. | 2.3% | Jasper County School District / 22,250 |
Please note that we only rank locations with 'United States American as First Ancestry Population Percentage' data. The rank above might not be a complete list. Locations without 'United States American as First Ancestry Population Percentage' data are not listed.
*ACS stands for U.S. Census American Community Survey. According to the U.S. Census, if the date is a range, you can interpret the data as an average of the period of time.
