| Rank | Percentage of Population Age 45 to 54 ▼ | School District / Population |
| 1. | 16.5% | York School District 2 / 34,368 |
| 2. | 16.2% | Lexington School District 5 / 91,018 |
| 3. | 16.2% | Fairfield County School District / 23,956 |
| 4. | 16.1% | Anderson School District 4 / 21,359 |
| 5. | 16.0% | Edgefield County School District / 26,985 |
| 6. | 15.9% | York School District 1 / 31,112 |
| 7. | 15.9% | Spartanburg School District 4 / 18,439 |
| 8. | 15.9% | Calhoun County School District / 15,175 |
| 9. | 15.8% | Dorchester School District 4 / 17,289 |
| 10. | 15.8% | Anderson School District 1 / 49,808 |
| 11. | 15.7% | York School District 4 / 49,865 |
| 12. | 15.7% | Lexington School District 3 / 13,248 |
| 13. | 15.7% | Lee County School District / 19,220 |
| 14. | 15.5% | Lexington School District 4 / 18,306 |
| 14. | 15.5% | Kershaw County School District / 61,697 |
| 16. | 15.5% | Union County School District / 28,961 |
| 17. | 15.4% | Lexington School District 1 / 121,030 |
| 18. | 15.4% | Orangeburg School District 3 / 20,121 |
| 18. | 15.4% | Barnwell School District 29 / 5,135 |
| 20. | 15.4% | Spartanburg School District 1 / 30,439 |
| 20. | 15.4% | Chester County School District / 33,140 |
| 22. | 15.3% | Laurens School District 55 / 37,250 |
| 23. | 15.2% | Anderson School District 3 / 15,156 |
| 24. | 15.2% | Clarendon School District 1 / 8,920 |
| 25. | 15.2% | Spartanburg School District 5 / 41,867 |
| 26. | 15.1% | Hampton School District 2 / 7,387 |
| 27. | 15.1% | Marlboro County School District / 28,933 |
| 28. | 15.1% | Barnwell School District 19 / 5,096 |
| 29. | 15.0% | Aiken County School District / 162,758 |
| 29. | 15.0% | Orangeburg School District 4 / 20,430 |
| 31. | 14.9% | Barnwell School District 45 / 12,382 |
| 31. | 14.9% | Chesterfield County School District / 46,734 |
| 33. | 14.9% | McCormick County School District / 10,233 |
| 34. | 14.9% | Clarendon School District 2 / 19,243 |
| 35. | 14.9% | Dillon School District 1 / 5,462 |
| 36. | 14.9% | Marion School District 7 / 6,077 |
| 37. | 14.8% | Greenwood School District 51 / 6,893 |
| 38. | 14.8% | Colleton County School District / 38,892 |
| 39. | 14.8% | Dillon School District 3 / 7,602 |
| 40. | 14.8% | Spartanburg School District 3 / 16,629 |
| 41. | 14.7% | Darlington County School District / 68,681 |
| 42. | 14.7% | Florence School District 4 / 6,768 |
| 43. | 14.7% | Dorchester School District 2 / 119,266 |
| 44. | 14.6% | Williamsburg County School District / 34,423 |
| 45. | 14.6% | Marion School District 2 / 11,648 |
| 46. | 14.6% | Anderson School District 2 / 22,394 |
| 47. | 14.5% | Hampton School District 1 / 13,703 |
| 48. | 14.5% | Richland School District 2 / 126,150 |
| 49. | 14.4% | Greenville County School District / 466,178 |
| 50. | 14.4% | Abbeville County School District / 24,326 |
| 51. | 14.3% | Spartanburg School District 6 / 58,687 |
| 51. | 14.3% | Berkeley County School District / 177,843 |
| 53. | 14.3% | Oconee County School District / 74,273 |
| 54. | 14.3% | Newberry County School District / 37,508 |
| 55. | 14.3% | Jasper County School District / 24,777 |
| 56. | 14.2% | Allendale County School District / 10,419 |
| 56. | 14.2% | Sumter School District 2 / 57,252 |
| 58. | 14.2% | Florence School District 1 / 96,463 |
| 58. | 14.2% | Greenwood School District 52 / 7,366 |
| 60. | 14.2% | Georgetown County School District / 60,158 |
| 60. | 14.2% | Bamberg School District 1 / 8,810 |
| 60. | 14.2% | Florence School District 5 / 5,943 |
| 63. | 14.2% | Cherokee County School District / 53,383 |
| 64. | 14.1% | Florence School District 3 / 20,584 |
| 65. | 14.0% | York School District 3 / 110,728 |
| 66. | 14.0% | Sumter School District 17 / 50,204 |
| 67. | 14.0% | Florence School District 2 / 7,127 |
| 68. | 13.9% | Spartanburg School District 2 / 58,308 |
| 69. | 13.9% | Lancaster County School District / 76,652 |
| 69. | 13.9% | Dillon School District 2 / 18,998 |
| 71. | 13.9% | Marion School District 1 / 15,337 |
| 72. | 13.8% | Anderson School District 5 / 78,592 |
| 73. | 13.8% | Lexington School District 2 / 63,322 |
| 74. | 13.8% | Horry County School District / 269,291 |
| 75. | 13.7% | Charleston County School District / 350,209 |
| 76. | 13.7% | Laurens School District 56 / 20,726 |
| 77. | 13.6% | Saluda County School District / 15,200 |
| 78. | 13.4% | Spartanburg School District 7 / 52,943 |
| 79. | 13.3% | Greenwood School District 50 / 58,872 |
| 80. | 13.3% | Pickens County School District / 119,224 |
| 81. | 13.0% | Orangeburg School District 5 / 51,950 |
| 82. | 13.0% | Richland School District 1 / 201,528 |
| 83. | 12.8% | Bamberg School District 2 / 7,177 |
| 84. | 12.3% | Clarendon School District 3 / 6,808 |
| 85. | 11.5% | Beaufort County School District / 161,206 |
| 86. | 1.8% | Richland County School District 2 within Fort Jackson / 14,309 |
| 86. | 1.8% | Fort Jackson Schools / 14,309 |
| 88. | 1.5% | Beaufort County School District within Beaufort Marine Corps Air Station / 1,027 |
| 88. | 1.5% | Beaufort Marine Corps Air Station School District / 1,027 |
Please note that we only rank locations with 'Percentage of Population Age 45 to 54' data. The rank above might not be a complete list. Locations without 'Percentage of Population Age 45 to 54' data are not listed.
