| Rank | Air Quality Index ▼ | School District / Population |
| 1. | 53.2 | Greenville County School District / 482,484 |
| 2. | 52.9 | Anderson School District 1 / 49,874 |
| 3. | 52.5 | Pickens County School District / 119,577 |
| 4. | 52.4 | Anderson School District 4 / 21,928 |
| 5. | 50.9 | Lexington School District 2 / 63,624 |
| 6. | 50.6 | Lexington School District 5 / 93,939 |
| 7. | 50.5 | Fort Jackson Schools / 14,761 |
| 7. | 50.5 | Richland School District 1 / 206,981 |
| 7. | 50.5 | Richland School District 2 / 128,949 |
| 7. | 50.5 | Spartanburg School District 6 / 61,345 |
| 7. | 50.5 | Richland County School District 2 within Fort Jackson / 14,761 |
| 12. | 50.5 | Kershaw County School District / 62,342 |
| 13. | 50.3 | Fairfield County School District / 23,382 |
| 14. | 50.2 | Spartanburg School District 2 / 58,913 |
| 15. | 50.1 | Anderson School District 5 / 79,906 |
| 16. | 50.0 | Spartanburg School District 5 / 42,810 |
| 17. | 49.9 | Spartanburg School District 1 / 29,714 |
| 18. | 49.8 | Spartanburg School District 7 / 53,770 |
| 19. | 49.6 | Spartanburg School District 4 / 18,504 |
| 20. | 49.5 | Spartanburg School District 3 / 16,307 |
| 21. | 48.8 | Lancaster County School District / 79,515 |
| 22. | 48.4 | Lexington School District 1 / 126,307 |
| 23. | 48.1 | Anderson School District 3 / 15,039 |
| 23. | 48.1 | Greenwood School District 51 / 7,101 |
| 25. | 48.0 | Allendale County School District / 10,027 |
| 26. | 47.8 | Edgefield County School District / 26,573 |
| 27. | 47.7 | Barnwell School District 45 / 11,915 |
| 28. | 47.5 | York School District 4 / 54,198 |
| 28. | 47.5 | Dillon School District 2 / 23,452 |
| 28. | 47.5 | Dillon School District 1 / 5,462 |
| 31. | 47.5 | Newberry County School District / 37,593 |
| 31. | 47.5 | Anderson School District 2 / 23,295 |
| 31. | 47.5 | Abbeville County School District / 23,891 |
| 34. | 47.3 | York School District 3 / 112,078 |
| 34. | 47.3 | Oconee County School District / 74,656 |
| 36. | 47.1 | York School District 2 / 36,439 |
| 37. | 46.8 | Chesterfield County School District / 46,333 |
| 37. | 46.8 | Union County School District / 28,329 |
| 39. | 46.7 | Laurens School District 56 / 20,894 |
| 40. | 46.6 | Marlboro County School District / 28,294 |
| 40. | 46.6 | York School District 1 / 32,570 |
| 40. | 46.6 | Lee County School District / 18,708 |
| 43. | 46.5 | Chester County School District / 32,708 |
| 44. | 46.5 | Lexington School District 3 / 12,749 |
| 45. | 46.4 | Cherokee County School District / 53,716 |
| 46. | 46.3 | Laurens School District 55 / 36,736 |
| 47. | 46.2 | Lexington School District 4 / 18,396 |
| 47. | 46.2 | Aiken County School District / 165,978 |
| 49. | 45.5 | Barnwell School District 29 / 5,368 |
| 50. | 45.4 | Greenwood School District 52 / 7,364 |
| 51. | 45.1 | Barnwell School District 19 / 5,004 |
| 51. | 45.1 | Greenwood School District 50 / 58,892 |
| 51. | 45.1 | McCormick County School District / 10,003 |
| 51. | 45.1 | Bamberg School District 2 / 7,038 |
| 55. | 44.9 | Orangeburg School District 5 / 50,688 |
| 56. | 44.8 | Sumter School District 2 / 57,252 |
| 56. | 44.8 | Calhoun County School District / 15,031 |
| 58. | 44.7 | Saluda County School District / 15,250 |
| 59. | 44.6 | Darlington County School District / 68,161 |
| 60. | 44.5 | Sumter School District 17 / 50,204 |
| 61. | 44.4 | Bamberg School District 1 / 8,611 |
| 61. | 44.4 | Orangeburg School District 4 / 20,108 |
| 63. | 44.1 | Hampton School District 1 / 13,195 |
| 64. | 43.8 | Hampton School District 2 / 7,475 |
| 65. | 43.3 | Florence School District 4 / 6,032 |
| 65. | 43.3 | Dillon School District 3 / 8,077 |
| 67. | 43.2 | Marion School District 2 / 11,648 |
| 68. | 43.0 | Jasper County School District / 26,042 |
| 68. | 43.0 | Beaufort Marine Corps Air Station School District / 949 |
| 68. | 43.0 | Beaufort County School District within Beaufort Marine Corps Air Station / 949 |
| 71. | 42.9 | Marion School District 1 / 15,337 |
| 71. | 42.9 | Florence School District 1 / 100,376 |
| 73. | 42.6 | Orangeburg School District 3 / 20,466 |
| 73. | 42.6 | Beaufort County School District / 167,504 |
| 73. | 42.6 | Florence School District 3 / 19,559 |
| 76. | 42.4 | Florence School District 5 / 5,213 |
| 77. | 42.3 | Marion School District 7 / 6,077 |
| 77. | 42.3 | Florence School District 2 / 6,878 |
| 79. | 42.2 | Clarendon School District 3 / 6,573 |
| 80. | 41.9 | Horry County School District / 283,280 |
| 80. | 41.9 | Williamsburg County School District / 33,560 |
| 82. | 41.5 | Clarendon School District 2 / 18,553 |
| 83. | 40.9 | Georgetown County School District / 60,389 |
| 84. | 40.7 | Dorchester School District 4 / 16,296 |
| 85. | 40.6 | Clarendon School District 1 / 9,313 |
| 86. | 40.3 | Colleton County School District / 38,247 |
| 87. | 40.0 | Dorchester School District 2 / 126,476 |
| 87. | 40.0 | Berkeley County School District / 188,835 |
| 89. | 39.5 | Charleston County School District / 365,674 |
Please note that we only rank locations with 'Air Quality Index' data. The rank above might not be a complete list. Locations without 'Air Quality Index' data are not listed.
