| Rank | Median Household Income ▼ | School District / Population |
| 1. | $57,917 | Kelso C-7 School District / 2,030 |
| 2. | $55,750 | Lick Creek Community Consolidated School District 16 / 1,080 |
| 3. | $53,409 | Leopold R-III School District / 1,036 |
| 4. | $52,148 | Nell Holcomb R-IV School District / 2,959 |
| 5. | $50,000 | Altenburg 48 School District / 1,159 |
| 6. | $49,551 | Jackson R-II School District / 28,804 |
| 7. | $48,860 | Meadow Heights R-II School District / 3,822 |
| 8. | $48,694 | Giant City Community Consolidated School District 130 / 2,344 |
| 9. | $44,946 | Perry County 32 School District / 17,662 |
| 10. | $44,775 | Scott County R-IV School District / 5,546 |
| 11. | $44,250 | Risco R-II School District / 673 |
| 12. | $44,125 | Cypress School District 64 / 901 |
| 13. | $43,431 | Oran R-III School District / 2,306 |
| 14. | $42,847 | Oak Ridge R-VI School District / 2,011 |
| 15. | $42,632 | Cobden School Unit District 17 / 3,705 |
| 16. | $41,250 | Delta R-V School District / 2,524 |
| 17. | $41,228 | Ballard County School District / 8,225 |
| 18. | $40,259 | Richland R-I School District / 1,930 |
| 19. | $40,156 | Anna Jonesboro Community High School District 81 / 11,336 |
| 20. | $39,936 | Cape Girardeau 63 School District / 37,975 |
| 21. | $39,792 | Bell City R-II School District / 1,409 |
| 22. | $39,115 | Joppa-Maple Grove Unit District 38 / 1,520 |
| 23. | $38,804 | Anna Community Consolidated School District 37 / 7,124 |
| 24. | $38,796 | Scott City R-I School District / 5,550 |
| 25. | $38,781 | Dexter R-XI School District / 12,529 |
| 26. | $38,553 | Dongola School Unit District 66 / 1,849 |
| 27. | $38,393 | Egyptian Community Unit School District 5 / 3,902 |
| 28. | $37,778 | Shawnee Community Unit School District 84 / 3,248 |
| 29. | $37,730 | Jonesboro Community Consolidated School District 43 / 3,132 |
| 30. | $37,165 | Fulton County School District / 3,692 |
| 31. | $37,034 | Century Community Unit School District 100 / 2,852 |
| 32. | $36,629 | Scott County R-II School District / 3,782 |
| 33. | $36,597 | Bernie School District / 3,497 |
| 34. | $36,150 | Puxico R-VIII School District / 4,836 |
| 35. | $35,513 | Portageville School District / 4,060 |
| 36. | $34,943 | East Prairie R-II School District / 5,655 |
| 37. | $34,615 | Marquand-Zion School District / 1,643 |
| 38. | $34,554 | Sikeston School District / 20,780 |
| 39. | $34,369 | Poplar Bluff R-I School District / 32,787 |
| 40. | $33,909 | Carlisle County School District / 5,126 |
| 41. | $33,701 | Fredericktown R-I School District / 10,506 |
| 42. | $32,694 | Unity Point Community Consolidated School District 140 / 5,451 |
| 43. | $32,571 | Advance R-IV School District / 3,233 |
| 44. | $32,491 | Murphysboro Community Unit School District 186 / 15,300 |
| 45. | $32,303 | Scott County Central Schools / 2,006 |
| 46. | $31,836 | Hickman County School District / 4,949 |
| 47. | $31,345 | Bloomfield School District / 4,477 |
| 48. | $30,716 | New Madrid County R-I School District / 9,827 |
| 49. | $30,125 | Zalma R-V School District / 1,792 |
| 50. | $29,467 | Clarkton C-4 School District / 1,783 |
| 51. | $29,000 | Buncombe Consolidated School District 43 / 523 |
| 52. | $28,602 | Meridian Community Unit School District 101 / 3,511 |
| 53. | $28,094 | Twin Rivers R-X School District / 5,557 |
| 54. | $27,939 | Greenville R-II School District / 5,211 |
| 55. | $27,589 | Gideon School District / 1,711 |
| 56. | $27,500 | Woodland R-IV School District / 5,413 |
| 57. | $26,736 | Malden R-I School District / 6,348 |
| 58. | $26,203 | Charleston R-I School District / 8,488 |
| 59. | $26,166 | Campbell R-II School District / 3,626 |
| 60. | $22,892 | Cairo Community Unit School District 1 / 3,096 |
Please note that we only rank locations with 'Median Household Income' data. The rank above might not be a complete list. Locations without 'Median Household Income' data are not listed.
*ACS stands for U.S. Census American Community Survey. According to the U.S. Census, if the date is a range, you can interpret the data as an average of the period of time.
